Dichloroquinolinic acid W.P.
Quinclorac
CAS: 84087-01-4;113875-40-4
Molecular Formula: C10H5Cl2NO2
Dichloroquinolinic acid W.P. - Names and Identifiers
Dichloroquinolinic acid W.P. - Physico-chemical Properties
| Molecular Formula | C10H5Cl2NO2 |
| Molar Mass | 242.06 |
| Density | 1.7500 |
| Melting Point | 274°C |
| Boling Point | 405.4±40.0 °C(Predicted) |
| Flash Point | 100°C |
| Solubility | Slightly soluble in acetone, ether, ethanol, ethyl acetate, etc., solubility 1~2 g/kg; Insoluble in toluene, n-octanol, dichloromethane, n-hexane, acetonitrile; Insoluble in water |
| Vapor Presure | 2.27E-07mmHg at 25°C |
| Appearance | White crystal |
| Color | Pale Yellow |
| BRN | 7761858 |
| pKa | -3.26±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.6100 (estimate) |
| MDL | MFCD00072495 |
| Physical and Chemical Properties | Pure white crystals. m. P. 274 °c, relative density 1.75, vapor pressure 0.01 x 10-3Pa (20 °c),pKa4.34 (20 °c). Slightly soluble in acetone, ethyl ether, ethanol, ethyl acetate, etc., solubility 1~2g/kg; Difficult to dissolve in toluene, octanol, dichloromethane, hexane, acetonitrile; Insoluble in water. Partition coefficient 0.07 (pH = 7). In light, heat and weak acid, weak base conditions stable, non-corrosive. |
| Use | Belongs to the hormone type of quinoline carboxylic acid herbicide, suitable for rice transplanting field or seedling field |
Dichloroquinolinic acid W.P. - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 43 - May cause sensitization by skin contact |
| Safety Description | S2 - Keep out of the reach of children. S24 - Avoid contact with skin. S37 - Wear suitable gloves. |
| WGK Germany | 2 |
| RTECS | VB1984000 |
| HS Code | 29334900 |
Dichloroquinolinic acid W.P. - Upstream Downstream Industry
| Raw Materials | 3-Chloro-2-methylaniline Glycerin Nitric acid |
Dichloroquinolinic acid W.P. - Reference
| Reference Show more | 1. [IF=7.171] et al."Isolation, Screening, and Degradation Characteristics of a Quinclorac-Degrading Bacterium, Strain D, and Its Potential for Bioremediation of Rice Fields Polluted by Quinclorac | Microbiology Spectrum."Microbiol Spectr. 2021 Oct;: 2. [IF=5.519] Xue Liu et al."Establishment and Comparative Analysis of Enzyme-Linked Immunoassay and Time-Resolved Fluoroimmunoassay for the Determination of Trace Quinclorac in Environment."Biosensors-Basel. 2022 May;12(5):338 |
Dichloroquinolinic acid W.P. - Nature
Open Data Verified Data
pure white crystals. The melting point is 274 ℃, the relative density is 1. 75, the vapor pressure (20 ℃) is 0.01 × 10-3 Pa, and the pK is at 20 ℃. 4. 34. Slightly soluble in acetone, ethyl ether, ethanol, ethyl acetate, difficult to dissolve in toluene, octanol, dichloromethane, hexane, acetonitrile; Insoluble in water. Octanol/water partition coefficient was 0. 07 (pH = 7). In light and heat and weak acid, weak base conditions, stable, non-corrosive.
Last Update：2024-01-02 23:10:35
Dichloroquinolinic acid W.P. - Preparation Method
Open Data Verified Data
O-nitrotoluene is chlorinated with chlorine at 35~45 ℃. Under the catalysis of ferric chloride and iodine, a mixture of O-nitrotoluene is obtained, 3 monochloro-2-methylaniline was obtained by hydrogenation and reduction. A quantitative amount of 3 monochloro-2-methylaniline, sulfuric acid and potassium iodide were added to the reaction kettle, and glycerol was added dropwise under stirring to obtain 7 monochloro-8-methylquinoline, and then in the dichlorobenzene of azobisisobutyronitrile, chlorine gas is introduced at 40 ° C. To generate 3,7-= chloro-8-chloromethylquinoline, which is then hydrolyzed by oxidation to obtain quinclorac.
Last Update：2022-01-01 10:13:07
Dichloroquinolinic acid W.P. - Use
Open Data Verified Data
belongs to the hormone type of quinoline carboxylic acid, a strong selective herbicide. For direct-seeding rice field and transplant paddy field, can effectively control the grass, Gleditsia sinensis, Sesbania and other weeds. The control effect of Humulus scandens is especially prominent. The control effect of the 4~7 leaf period is also very prominent, a spraying control of the whole rice growth period of the whole rice grass, in addition to the control of the duck tongue grass, cress and other weeds.
Last Update：2022-01-01 10:13:07
Dichloroquinolinic acid W.P. - Safety
Open Data Verified Data
The LD50 of the original drug for rats was 2190~3060mg/kg, mice> 5000mg/kg; Rat percutaneous LD50>2000mg/kg, inhalation of LC50>5.17mg/L(4H) in rats had no irritating effect on rabbit skin and eyes. Rainbow trout LC50 >lOOmg/L, Daphnia LC50 500g/m3 (3H), quail oral LD50>2000mg/kg, harmless to bees.
Last Update：2022-01-01 10:13:08
Dichloroquinolinic acid W.P. - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| active drug substance | common name in English quinclorac other names: quick Killer, Killer, gram star, Facet,BAS-51406-H. Toxicity is low toxicity herbicides. Rat acute oral LD502680 mg/kg, rat percutaneous LD50>2000 mg/kg. Acute inhalation LC50 (4 hours) >5.2 mg/L, fish, Bee non-toxic. Dosage Form 25%, 50% wettable powder. Characteristic is hormone-type quinoline carboxylic acid herbicides, weed poisoning symptoms and auxin class similar to the role, mainly for the control of Humulus scandens and the pot life is very long, 1-7 leaf stage are effective. Rice is safe. The scope of application is mainly used for rice field anti-weed. It can also prevent and control the rainy flowers, sesbania, cress, duck tongue grass, Gleditsia sinensis. Method of use 1. In the transplanting field, the grass can be applied at 1-7 leaf stage, with 13.5-26 grams of active ingredient per mu, spray, drain water before medicine, release water back to the field after medicine, maintain 3-5cm water layer. After 2.5 leaf stage of seedling in direct seeding field, the dosage was the same as above. Note: 1. The residual amount in the soil is large, which is easy to cause the damage to the post, and the post can be used to grow rice, corn and sorghum. 2. Solanaceae (tobacco, potato, pepper, etc.), Umbelliferae (carrot, celery), Chenopodiaceae (spinach, beet), malabaceae, Cucurbitaceae (all kinds of Cucurbitaceae), legaceae, Compositae, the crops of the family are sensitive to the drug. 3. It can be used in combination with melittin, bensulfuron-methyl, diopter, etc. |
| phytotoxicity | quinclorac is a common herbicide used to control the rice fields of Humulus scandens. The drug can be germinated seeds, roots and leaves absorption, with the characteristics of hormone herbicides, and the role of auxin similar symptoms. The root of rice can decompose quinclorac, thus it is safe for rice. Quinclorac used before the 2-leaf stage of rice, easy to produce damage, the performance of rice tillering stage leaves scattered, not Tiller, and produce onion tubular leaves. Before the 3-leaf stage of rice, quinclorac should not exceed 25g of pure medicinal dose per mu (equivalent to 50g of 50% quinclorac wettable powder). Excessive use of quinclorac, or uneven spray and repeated application of drugs, prone to Phytotoxicity, the damaged rice leaves were dark green, Tiller occurred slowly, later appeared onion tubular leaves. Light injury to the seedling, stem base expansion, hardening, brittle, Heart leaf narrowing and twisted into deformity. The symptoms of phytotoxicity usually appear 10 to 15 days after administration. In recent years, it is generally found that the effect of quinclorac on the control of older Humulus scandens with more than 4 leaves stage is not good in the production. Especially in the dry direct-seeding rice field, in the rice 2 leaves 1 heart to 3 leaf stage, the field of older Humulus is usually in the 4 leaf stage or more, the dosage of quinclorac should be increased to effectively control, the per mu dosage of 50% quinclorac wettable powder before and after the 3-leaf stage in direct-seeding rice production is generally about 50g. With the increase of dosage, the risk of injury of quinclorac is increased, and a large area of rice is damaged every year. In recent years, some farmers have mixed drugs with quinclorac, such as Qianjin, with good safety, Not only to ensure the control effect, quinclorac dosage is not too high, the risk of drug damage is relatively reduced. The highly safe stem and leaf treatment agents such as Oryza sativa, Qianjin and the like replace quinclorac in a large area, and also relatively reduce the occurrence of quinclorac phytotoxicity. |
| toxicity | Acute Oral LD5030100mg/kg in rats and> 4400mg/kg in mice; rat acute percutaneous LD50>2000mg/kg, rat acute inhalation LC50>5.17mg/L (4H). There was no irritation to rabbit skin and eyes. The rats were fed a non-effective dose of 533mg/kg feed for 2 years. No carcinogenic, teratogenic, mutagenic effects. Rainbow trout LC50>100mg/L, Daphnia lc50500 g/m3(3H), quail acute oral LD50>2000mg/kg. The bee is non-toxic. |
| Use | a hormone-type herbicide selected from the paddy field: Hongcao. The control effect of the 4~7 leaf period is also very prominent, and the whole growth period of rice is controlled by one application. In addition, it can also control weeds such as duck tongue grass and cress. The recommended dosage of 13.3~26.7g/100 m2, the water spray. Generally in the rice transplanting field after transplanting, Humulus scandens 1~3.5 leaf stage application. used as a herbicide in paddy field used to control a variety of Gramineae, such as humulus scandens, Magang, bezoar, qianjincao, heterotypic Cyperus papyrifera, node vegetables, Xanthium sibiricum, hemp, etc, belongs to the hormone type of quinoline carboxylic acid herbicides, suitable for rice transplanting field or rice field direct seeding field |
| production method | preparation method 1 under the catalysis of ferric chloride and sulfonic acid, O-nitrotoluene is chlorinated at 35~45 ℃, the mixture of chloro-o-nitrotoluene was obtained, and 3-chloro-2-methylnitrobenzene was separated by refining. The product was reduced by hydrogenation to obtain 3-chloro-2-toluidine. Quinclorac is obtained by Surup cyclization, chlorination, oxidation and hydrolysis. Preparation Method 2 |
| category | pesticide |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 2190 mg/kg; Oral-mouse LD50: 5000 mg/kg |
| flammability hazard characteristics | toxic nitrogen oxides and chloride gases from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| extinguishing agent | dry powder, foam, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:53
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Product Name: Quinclorac Visit Supplier Webpage Request for quotationCAS: 84087-01-4
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Raw Materials for Dichloroquinolinic acid W.P.